Gene information
Official symbol HBEGF
Official full name heparin binding EGF like growth factor
Gene type protein-coding gene
Chromosome5q31.3
Previous symbolHEGFL; DTS; DTR
Resources
Entrez Gene 1839
HGNC HGNC:3059
Ensembl ENSG00000113070
Vega OTTHUMG00000129496
UCSC uc003lfi.4
GO terms: 62 records
GO Description Category LogP Number of genes Detail
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002009 morphogenesis of an epithelium GO Biological Processes -21.4354199 71 More
GO:0002011 morphogenesis of an epithelial sheet GO Biological Processes -2.28104559 7 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007517 muscle organ development GO Biological Processes -15.8908392 49 More
GO:0008016 regulation of heart contraction GO Biological Processes -27.6827716 55 More
GO:0008047 enzyme activator activity GO Molecular Functions -1.49794348 13 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0019207 kinase regulator activity GO Molecular Functions -2.87704457 10 More
GO:0019209 kinase activator activity GO Molecular Functions -2.38668070 6 More
GO:0019887 protein kinase regulator activity GO Molecular Functions -2.69690139 9 More
GO:0030295 protein kinase activator activity GO Molecular Functions -2.50130986 6 More
GO:0030307 positive regulation of cell growth GO Biological Processes -13.7154299 34 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0032147 activation of protein kinase activity GO Biological Processes -11.6086663 28 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0038127 ERBB signaling pathway GO Biological Processes -2.50267494 8 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway GO Biological Processes -3.18614571 7 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0045927 positive regulation of growth GO Biological Processes -20.3035639 52 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048661 positive regulation of smooth muscle cell proliferation GO Biological Processes -29.0732096 40 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.9747849 34 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061061 muscle structure development GO Biological Processes -23.2569142 77 More
GO:0061097 regulation of protein tyrosine kinase activity GO Biological Processes -4.69934335 14 More
GO:0061098 positive regulation of protein tyrosine kinase activity GO Biological Processes -4.90193440 11 More
GO:0090303 positive regulation of wound healing GO Biological Processes -15.9447313 16 More
GO:1901184 regulation of ERBB signaling pathway GO Biological Processes -3.96203474 12 More
GO:1901186 positive regulation of ERBB signaling pathway GO Biological Processes -3.03839152 7 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1903018 regulation of glycoprotein metabolic process GO Biological Processes -5.51204462 13 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903036 positive regulation of response to wounding GO Biological Processes -14.4451296 16 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000273 positive regulation of signaling receptor activity GO Biological Processes -8.61037442 14 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa04928 Parathyroid hormone synthesis, secretion and action KEGG Pathway -3.30201840 7 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05205 Proteoglycans in cancer KEGG Pathway -18.5545131 27 More
Drug-Gene interaction
view
Related drugs: 3 records
Drug name Interaction type Source PMID View
cetuximab PharmGKB view
khk-2866 TTD view
panitumumab PharmGKB view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
proheparin-binding EGF-like growth factor proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Vukovic Dejanovic V et al. Scand J Clin Lab Invest. 2019
proheparin-binding EGF-like growth factor proteomics good predictor acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Dejanovic VV et al. Angiology. 2020
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